We find that Orai channel clustering creates spatially distinct

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steriods We compare the predictions of the model to expected biological outcomes and then use the model to investigate how the placement of Orai channels, and in particular how clustering of Orai channels, creates spatially distinct calcium profiles. We then examine whether the spatial calcium profile affects ER refilling and what factors control ER refilling.We find that Orai channel clustering creates spatially distinct calcium profiles within the ER PM junction but does not enhance ER refilling. ER refilling is more strongly controlled by the proximity of SERCA pumps to Orai channels. steriods

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